David Staněk, PhD
Group-leader, Laboratory of RNA Biology, Institute of Molecular Genetics, Czech Academy of
Sciences, Prague, Czech Republic
David’s group’s long-term interest is to determine how cells decode information stored in the
genome. Particularly, his group is interested in snRNP and spliceosome assembly, regulation of
pre-mRNA splicing in the context of the cell nucleus and splicing of non-coding RNAs. Using
advanced microscopy techniques (e.g. live cell imaging, FRET, FRAP and FCS) they explore where
and when snRNPs and the spliceosome assemble in the cell nucleus. The group also studies the
regulatory circuits between splicing, chromatin and transcription and aim to understand the role
of chromatin environment on the splicing outcome.