Gene Yeo, UCSD University
Gene's lab developed eCLIP and is a core member of ENCODE RNA. It uses high-throughput assays to
study the molecular mechanisms and biological impact underlying alternative splicing,
polyadenylation, transport, translation, RNA turnover and microRNA biology.
The lab also develops machine-learning approaches to single cell RNA-seq/DNA analysis and
visualization. A third line of research is targeting RNA in live cells using the CRISPR/Cas9
technology, pursuing therapeutic intervention of neuromuscular diseases.
The disease focus of the Yeo lab is on the molecular basis of mental disorders such as autism
spectrum disorders and neurodegenerative diseases (ALS), using in vitro stem cell models and in
vivo mice models.